MyBioSource.com's MOUSE ANTI HUMAN C4c is a Mouse monoclonal antibody. The MOUSE ANTI HUMAN C4c Antibody was generated using C4, C4A, C4A4, C4B, C4S, CH, Complement C4a, Complement C4b, complement component 4B (Chido blood group), copy 2, Miscellaneous, RG, and C4B_2 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
Mouse anti Human C4c antibody, clone 10-12 recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kDa) and alpha 3 (25 kDa) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma